Yong-bin Chen
Principle Investigator
Tumor Signal Transduction
Kunming Institute of Zoology
China
Biography
Prof. Yong-Bin Chen, Principle Investigator, Kunming Institute of Zoology, Chinese Academy of Sciences. Dr. Chen’s research is mainly focusing on characterizing molecular mechanisms of signaling pathways which are important for tumor and stem cells, such as Hedgehog (Hh) and Hippo (Hpo) signaling pathways. His lab is also establishing tumor models in the non-human primate animals including tree shrew and monkey, developing lead compounds screening platforms for serial tumors and adult neural stem cells which are isolated from human, monkey, tree shrew and mouse hippocampal dentate gyrus. Dr. Chen’s research results have been published in high profile journals, such as Genes & Development, Developmental Cell, PLoS Biology, PNAS, Cell Research, etc.
Research Interest
Inductive signals involved in regulating tumor and stem cells.
Publications
-
Tang, J.J., Zhang L., Jiang, L.P., Di, L., Yan, Y.M., Tu, Z.C., Yang, C.P., Zuo, Z.L., Hou, B, Xia, H.L., Chen, Y.B., Cheng Y.X.2014. Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation.Tetrahedron.70:8852-8857.Â
-
Su,Z.Y., Yang,Z.Z., Xu, Y.Q., Chen, Y.B., Yu, Q., 2015. MicroRNAs in apoptosis, autophagy and necroptosis. Oncotarget, 6:8474-8490.Â
-
Yan, Y.M., Wang, X.L., Luo, Q., Jiang, L.P., Yang, C.P., Hou, B., Zuo, Z. L., Chen, Y.B., Cheng, Y.X., 2015. Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation. Phytochemistry. 114:155-162.
