Yong-tang Zheng
Principle Investigator
Molecule Immunopharmcology
Kunming Institute of Zoology
China
Biography
Prof. Yong-Tang Zheng, Principle Investigator, Deputy Director, Kunming Institute of Zoology, Chinese Academy of Sciences. AIDS prevention and control is the major national strategic needs. To carry out basic, forward-looking research and application, our research is mainly focused on HIV/AIDS studies, including anti-HIV drugs, the AIDS primate animal models, the mechanism of antiviral restriction factors TRIM5α to HIV infection , HIV Molecular Epidemiology in Mekong River region. Ten book chapters and more than 310 papers have been published, including 199 SCI papers in PNASã€AIDSã€Nucleic Acids Resã€J Immuolã€Retrovirologyã€JMCã€JAIDS ect. Application and joint applications for 50 patents, 26 patents authorized. Six provincial and ministerial level award were gained, including The 1st Yunnan province Science and Technology Progress Award and The 2nd Natural Science Award. 20 people obtained PhD and 20 people obtained Master degree.
Research Interest
Study anti-HIV activities and mechanisms of compounds, Establish non-human primate model for studying the immunopathogenic mechanism of HIV/AIDS, MHC genetics research in primates of China, Study the restriction mechanism of antiviral restriction factors TRIM5α and TRIMCyp to HIV-1 infection, HIV cross-border spread in Mekong River region, including molecular epidemiology and HIV resistance
Publications
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Wang JH, Nie HL, Tam SC, Huang H, Zheng YT. Antiâ€HIVâ€1 property of trichosanthin correlates with its ribosome inactivating activity. FEBS letters. 2002 Nov 6;531(2):295-8.
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Zhang XJ, Yang GY, Wang RR, Pu JX, Sun HD, Xiao WL, Zheng YT. 7, 8â€Secolignans from Schisandra wilsoniana and their antiâ€HIVâ€1 activities. Chemistry & biodiversity. 2010 Nov 1;7(11):2692-701.
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Hu G, Li X, Zhang X, Li Y, Ma L, Yang LM, Liu G, Li W, Huang J, Shen X, Hu L. Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays. Journal of medicinal chemistry. 2012 Oct 22;55(22):10108-17.
