Liu Zewen

Biography

Liu Zewen, male, PhD, professor of insects, doctoral tutor. 1999-2004 Nanjing Agricultural University Department of Entomology Master, Bo Lian read postgraduate. Master's stage is to investigate the BPH resistance to commonly used pesticides to study the biochemical mechanism of organophosphate resistance, while screening for the brown planthopper resistance to neonicotinoid insecticide imidacloprid resistance risk assessment. During the Ph.D. phase, we continued to screen for the resistance of N. lugens to imidacloprid. After obtaining a high resistant strain, we focused on the mechanism of resistance of N. lugens to imidacloprid, cloning resistance-related genes, searching for drug-resistant mutation sites and establishing drug resistance molecular monitoring techniques. Visiting scholar, Lausanne Experimental Station, UK, 2004-2005. With the support of bilateral cooperation projects, we mainly expressed the acetylcholine receptor gene of BPH in vitro and isolated and purified the receptor protein. Using the drug target molecule interaction test, the functional mutations found were validated to identify the resistance mutation sites of acetylcholine receptor point. Postdoctoral fellow, University of London, UK, 2005-2006. With the aid of the Royal Society Scholarship, electrophysiological techniques were used to detect the function of acetylcholine receptors in wild-type and mutant-type N. lugens expressed in vitro to further reveal the effects of target mutations on the normal physiology of N. lugens and to study the effects of mutations on other neonicotinoid Insecticide sensitivity analysis of neonicotinoid insecticide and target interaction mechanism. Since 2006, Nanjing Agricultural University to introduce talent, Professor. The introduction of funds, based on the original 211 in the building, based on the further configuration of equipment, the establishment of insect molecular biology laboratory and gene expression technology platform to study the structure of insect target molecules and drug interactions with the molecular mechanism for the development of efficient Safety New insecticides provide new theories and new ways. 

Research Interest

Insect Molecular Biology and Gene Function Research