Gao Daming
Professor
Biochemistry and Cell Biology
Shanghai Institutes for Biological Sciences
China
Biography
GAO Daming is a Professor Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China. 54921281 dgao@@sibcb.ac.cn Research Interests: One major feature of cancer cells is that they could divide unlimitedly. Many cellular alterations contribute to this phenotype, including signaling pathways involved in cell cycle progression, signaling transduction, and cell survival. My research interests mainly focus on defining the basic regulatory mechanisms, especially the key post-translational modifications of important signaling transducers, controlling cancer cell proliferation and metabolism, which may reveal novel cancer-specific signaling axis and lead to identification of new therapeutic targets for cancer treatment.
Research Interest
One major feature of cancer cells is that they could divide unlimitedly. Many cellular alterations contribute to this phenotype, including signaling pathways involved in cell cycle progression, signaling transduction, and cell survival. My research interests mainly focus on defining the basic regulatory mechanisms, especially the key post-translational modifications of important signaling transducers, controlling cancer cell proliferation and metabolism, which may reveal novel cancer-specific signaling axis and lead to identification of new therapeutic targets for cancer treatment.
Publications
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Inuzuka H*, Gao D*, Finley L, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, and Wei W. Acetylation-Dependent Regulation of Skp2 Function. Cell, 2012, 150: 179-93.
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Gao D*, Inuzuka I*, Tan M*, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW and Wei W. mTOR drives its own activation via SCFb-TRCP-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell, 2011, 44: 290-303.
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Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennet E, Tron AE, Gasser JA, Lau A, Gygi S, Harper JW, DeCaprio JA, Toker A and Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell, 2010, 39: 797-808.
