Gao Dong
Professor
Biochemistry and Cell Biology
Shanghai Institutes for Biological Sciences
China
Biography
GAO Dong is a Professor, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China. Research Areas: Patients derived organoid model system, prostate stem cells, target therapy and drug resistant Research Interests: The tumor response to most therapeutic agents in cancer is highly unpredictable. Cancer models which can adequately represent tumor heterogeneity and predict in vivo drug sensitivity are intense areas of investigation. Recently, cancer “organoid” culture conditions have been developed to establish in vitro growth of patient-derived samples at higher efficiency and they are very promising for large scale drug screening and fundamental cancer biology research. In this laboratory, we combine organoid culture system, bioinformatic analysis and genetic engineered mouse models to define and characterize prostate luminal progenitor cells and prostate cancer progenitor cells, to develop new biomarker of advanced prostate cancers, to establish in vitro cancer organoids at different stage, to study drug resistant with tumor microenvironment and tumor cells plasticity, to establish Chinese patients derived cancer organoid bank.
Research Interest
The tumor response to most therapeutic agents in cancer is highly unpredictable. Cancer models which can adequately represent tumor heterogeneity and predict in vivo drug sensitivity are intense areas of investigation. Recently, cancer “organoid” culture conditions have been developed to establish in vitro growth of patient-derived samples at higher efficiency and they are very promising for large scale drug screening and fundamental cancer biology research. In this laboratory, we combine organoid culture system, bioinformatic analysis and genetic engineered mouse models to define and characterize prostate luminal progenitor cells and prostate cancer progenitor cells, to develop new biomarker of advanced prostate cancers, to establish in vitro cancer organoids at different stage, to study drug resistant with tumor microenvironment and tumor cells plasticity, to establish Chinese patients derived cancer organoid bank.
Publications
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Gao D and Chen Y. Organoid Development in Cancer Genome Discovery. Current Opinion in Genetics and Development. 2015 Mar 18; 30:42-48.
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Gao D*, Vela I*, Sboner A*, Iaquinta PJ*, Karthaus WL, Gopalan A, Wanjala JN, Dowling C, Undvall EA, Wongvipat J, Kossai M, Barboza LP, Di W, Cao Z, Zhang QF, Sirota I, Ran Ll, Solomon SB, MacDonald TY, Beltran H, Mosquera J, Eastham JA, Touijer KA, Scardino PT, Laudone VP, Rathkopf DE, Morris MJ, Danila DC, Slovin SF, Chi P, Clevers H, Carver B, Rubin MA, Scher HI, Sawyers CL, Chen Y. Generation of in vitro organoids cultures derived from patients with advanced prostate cancer. Cell, 2014 Sep; 159: 176-187.
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Drost J*, Karthaus WR*, Gao D, Driehuis E, Sawyers CL, Chen Y and Clevers H. Organoid culture systems for prostate epithelial tissue and prostate cancer tissue. Nature Protocols.
