Jing Naihe

Biography

JING Naihe is a Professor of Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, hanghai, China. Research Areas: neurogenesis; neural induction; neural development; neural stem cells; ES cell neural differentiation; BMP signaling; Alzheimer´s disease; chick embryos. Research Interests: Our long-term goal is to understand molecular mechanisms of CNS development and embryonic stem (ES) cell neural differentiation. There are two main stages during CNS development. The first stage is the neural induction, in which the pluripotent stem cells become the neural stem cells, and the second stage is the neurogenesis, in which the neural stem/progenitor cells proliferate and differentiate into neurons and glial cells. In both stages, the BMP signaling pathway plays important roles. In the neural induction process, BMP pathway inhibits neural fate determination of pluripotent stem cells. Whereas BMP signaling maintains neural stem cell pool and inhibits neural progenitor cells to differentiate into neurons. Using mouse ES and early chick embryos neural development as in vivo model, we are trying to find the down-stream targets and epigenetic regulation mechanisms of BMP pathway in its inhibition of neural induction. We are also studying the cross-talk between BMP and other signaling pathways during neuronal differentiation of neural progenitor cells.

Research Interest

Our long-term goal is to understand molecular mechanisms of CNS development and embryonic stem (ES) cell neural differentiation. There are two main stages during CNS development. The first stage is the neural induction, in which the pluripotent stem cells become the neural stem cells, and the second stage is the neurogenesis, in which the neural stem/progenitor cells proliferate and differentiate into neurons and glial cells. In both stages, the BMP signaling pathway plays important roles. In the neural induction process, BMP pathway inhibits neural fate determination of pluripotent stem cells. Whereas BMP signaling maintains neural stem cell pool and inhibits neural progenitor cells to differentiate into neurons. Using mouse ES and early chick embryos neural development as in vivo model, we are trying to find the down-stream targets and epigenetic regulation mechanisms of BMP pathway in its inhibition of neural induction. We are also studying the cross-talk between BMP and other signaling pathways during neuronal differentiation of neural progenitor cells.