Li Lin
Professor
Biochemistry and Cell Biology
Shanghai Institutes for Biological Sciences
China
Biography
LI Lin is a Professor of Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, hanghai, China. Research Areas: Wnt signalling; LRP5/6-Axin; Caprin-2; ZBED3; Myogenesis;beta-catenin-I-mfa; Transcriptional activation; Dvl-c-Jun; yeast two-hybrid; phosphoproteomics; zebrafish; rhodopsin/GRKs; ROCK/PTEN. Research Interests: Our laboratory has a long-standing interest in understanding the molecular mechanisms of Wnt signaling pathway. One part is focused on how the endogenous signal molecules cooperate in a multi-component complex manner in specific signal events, which we now concentrate mainly on signal processes nearby the cell membrane or in nucleus. Another part, we are also interested in how Wnt signal play roles in developing embryo and ES cells directional differentiation, and investigate the molecular basis of Wnt signaling function at the level of the organism. In addition, as it have been reported aberrantly activated Wnt leads to cancer, we wish to find out, based on a high-throughput screen, novel small-molecules which may downregulate Wnt signal especially at downstream of β-catenin stabilization and, simultaneously, reveal the potential targets for cancer treatment.
Research Interest
Our laboratory has a long-standing interest in understanding the molecular mechanisms of Wnt signaling pathway. One part is focused on how the endogenous signal molecules cooperate in a multi-component complex manner in specific signal events, which we now concentrate mainly on signal processes nearby the cell membrane or in nucleus. Another part, we are also interested in how Wnt signal play roles in developing embryo and ES cells directional differentiation, and investigate the molecular basis of Wnt signaling function at the level of the organism. In addition, as it have been reported aberrantly activated Wnt leads to cancer, we wish to find out, based on a high-throughput screen, novel small-molecules which may downregulate Wnt signal especially at downstream of β-catenin stabilization and, simultaneously, reveal the potential targets for cancer treatment.
Publications
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Jia Shen, Xiangpeng Sheng, ZeNan Chang, Qian Wu, Sheng Wang, Zongliang Xuan, Dan Li, Yalan Wu, Yongjia Shang, Xiangtao Kong, Long Yu, Lin Li, Kangchen Ruan, Hongyu Hu, Ying Huang, Lijian Hui, Dong Xie, Fudi Wang, and Ronggui Hu* (2014) Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. Cell Reports, 7, 1-14.
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Zhengzhao Liu, Peng Chen, Hong Gao, Yu Gu, Jiao Yang, Hong Peng, Xingxing Xu, Haifeng Wang, Meiqiang Yang, Xiaoying Liu, Libin Fan, Shiyao Chen, Jian Zhou, Yihong Sun, Kangchen Ruan, Shuqun Cheng, Masaaki Komatsu, Eileen White, Lin Li, Hongbin Ji, Daniel Finley, Ronggui Hu* (2014) Ubiquitylation of autophagy receptor optineurin. Cancer Cell, 26, 106-120.
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Chao Wang, Wenxiang Zhang, Meng-Xin Yin, Lianxin Hu, Peixue Li, Jiajun Xu, Hongling Huang, Shimin Wang, Yi Lu, Wenqing Wu, Margaret S. Ho, Lin Li, Yun Zhao, and Lei Zhang* (2015) Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis. Nature Communications, in press.
