Liu Xiaolong

Biography

LIU Xiaolong is a Professor of Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, hanghai, China. Research Areas thymocyte; TCR gene recombination; CD4/CD8 lineage differentiation; T cell activation and function; Tanscription Factors; DNA methylation; histone acetylation; non-coding RNA; Transgenic and knockout mice Research Interests: His lab is interested in the molecular mechanisms of thymocyte development, including (1) how the ordering and allelic exclusion of T cell receptor (TCR) gene recombination are achieved, (2) how TCR signaling and its downstream effectors control positive/negative selection and (3) how transcription factors determine the CD4/CD8 lineage commitment. We are also interested in how peripheral T cells collaborate with other immune cells to control immune response. Currently, our research approaches include biochemical, molecular biological and immunological techniques, large-scale gene expression profiling and analysis of transgenic and knockout mice.

Research Interest

His lab is interested in the molecular mechanisms of thymocyte development, including (1) how the ordering and allelic exclusion of T cell receptor (TCR) gene recombination are achieved, (2) how TCR signaling and its downstream effectors control positive/negative selection and (3) how transcription factors determine the CD4/CD8 lineage commitment. We are also interested in how peripheral T cells collaborate with other immune cells to control immune response. Currently, our research approaches include biochemical, molecular biological and immunological techniques, large-scale gene expression profiling and analysis of transgenic and knockout mice.