Song Jianguo

Biography

SONG Jianguo is a Professor Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Research Areas: epithelial-mesenchymal transition; Apoptosis; TGF-beta; Cell differentiation; Adipogenesis; Insulin receptor substrate-1; Nitric oxide; Ceramide; Protein kinase A; STAT3; secretory phospholipase A2; Ferritin heavy chain; Labile iron pool; Phospholipase; Lipid messenger.

Research Interest

Cellular fates and functions are controlled by various signaling events orchestrated via complex signaling networks. EMT and apoptosis have been implicated in various physiological and pathological processes such as embryonic development, body homeostasis, fibrotic diseases of liver and lung, tumor progress and metastasis. We are interest in studying the mechanisms of cell death-survival and differentiation. The studies have been focused on the signaling mechanisms through which the cell EMT and apoptosis were regulated by TGF-β1. The general questions we are attempting to answer include: 1. What biologically significant protein molecules are involved in TGF-β1-mediated EMT and cell apoptosis, and what specific roles the molecules in question play in these events? 2. What signaling pathways are implicated in the control of EMT and cell apoptosis? 3. How are the different cellular responses in mouse hepatocytes (apoptosis and EMT) been elicited by TGF-β. We are also interest in determining whether and how epigenetic regulation has been involved in the control of EMT and cell apoptosis. These studies may be of helpful in identifying and developing novel mechanism-based molecular targets for therapeutic application.