Tong Ming-han
Professor
Biochemistry and Cell Biology
Shanghai Institutes for Biological Sciences
China
Biography
TONG Ming-Han is a Professor Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Research Interest
Male factor infertility occurs in about 10% of men. Normal fertility in the male depends on spermatogenesis for the constant production of sperm throughout the life of the male. Spermatogenesis is highly coordinated and very complex, involving three major biological fundamentals (1) mitosis: the self-renewal of spermatogonial stem cells (SSCs) and the expansion of their progenitor cells; (2) meiosis: the reduction of the chromosome numbers by one-half in parent cells; (3) spermiogenesis: the unique remodeling of round haploid cells into mobile cells with flagella. Research in the Tong laboratory focuses on mammalian spermatogenesis. The primary goal of the Tong laboratory is the use of molecular and cellular techniques and in vivo animal model systems to uncover basic mechanisms responsible for the fate decision of SSCs and the initiation of meiosis, with the aim being to make the spermatid in the culture dish.
Publications
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Tong MH, Jiang H, Liu P, Lawson JA, Brass LF, Song WC. 2005 Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Nat Med. 11(2): 153-159.
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Ming-Han Tong*, Debra Mitchell, Samantha McGowan and Michael D.Griswold* 2012 Two miRNAs Clusters, Mir-17-92 and Mir-106b-25, Are Involved in the Regulation of Spermatogonial Differentiation. Biol Reprod. 86(3): 72 1-10.
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Ming-Han Tong, Debra Mitchell, Ryan Evanoff and Michael D.Griswold 2011 Expression of Mirlet7 Family MicroRNAs in Response to Retinoic Acid-Induced Spermatogonial Differentiation in Mice. Biol Reprod. 85 (1): 189-197.
