Wang Enduo
Professor
Biochemistry and Cell Biology
Shanghai Institutes for Biological Sciences
China
Biography
WANG Enduo is a Professor Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Research Areas: aminoacyl tRNA synthetase; aminoacylation; editing; LeuRS; ArgRS.
Research Interest
The fidelity of protein synthesis is dependent on accurate substrate recognition by the aminoacyl-tRNA synthetase (aaRS) which catalyzes the first step reaction of protein biosynthesis, aminoacylation of tRNA. Each recognizes a single cognate amino acid and covalently attaches it to the correct tRNA. Some aaRSs misactivate incorrect amino acids, but have evolved mechanisms to proofread their errors and edit their mistakes. I am interested in understanding the mechanistic details and molecular interactions that govern aaRS aminoacylation and editing activities. Results from these investigations address basic research questions and also target long-term applications such as antibiotic development. My lab has focused on leucyl-, arginyl- and methionyl- tRNA synthetases to carry out the investigation.
Publications
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Ru-Juan Liu, Tao Long, Jing Li, Hao Li, En-Duo Wang*,Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6. Nucleic Acids Res.,2017.
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Qing Ye, Quan-Quan Ji, Wei Yan, Fang Yang, En-Duo Wang*,Acetylation of lysine ε-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli. J. Biol. Chem.,First Published onApril 28, 2017.
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Quan-Quan Ji, Zhi-Peng Fang, Qing Ye, Cheng-WuChi, En-Duo Wang*,Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain.Nucleic Acids Res.,2017.
