Wang Gang

Biography

WANG Gang is a Professor Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Research Areas: Signaling and gene regulation of cancer and stem cells; Mediator complex.

Research Interest

Mediator complex was originally identified as a molecular bridge between activators and Pol II required for activation in vitro and in vivo. Our previous research demonstrated that, 1) The major form of the cellular Mediator Complexes are the large (>1.5 MD) Mediator Complexes with some hereogeneity, distinguished by the presence or absence of the CDK8/cyclin C submodule; 2) Adenovirus large E1A protein interacts with Mediator in vivo during adenoviral infection and transformation; 3) Mediator Med23 (Sur2) forms a Mediator submodule with two other subunits, Med16 and Med24; and 4) In addition to the simplistic "recruitment" role for promoting preinitiation complex (PIC) formation, Mediator also function at a post-recruitment step to stimulate transcription. My future research will combine the approaches of protein biochemistry, molecular biology, and genomics/proteomics to further analyze the functional relationship of Mediator to other molecular and cellular events, such as the coupling of the signal transduction and gene expression, chromosomal modification and remodeling, cell growth and differentiation, and cancer development.