Zeng Rong
Professor
Biochemistry and Cell Biology
Shanghai Institutes for Biological Sciences
China
Biography
ZENG Rong is a Professor Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Research Areas: proteomics;mass spectrometry;high-throughput protein identification; protein-protein interaction network;protein dynamics; quantitiative proteomics;subcelluar proteomics;adipocyte differentiation; diabetes.
Research Interest
1. Methodology development in Proteomics: Develop mass spectrometry based methods including multi-dimensional LC-MS/MS for protein profiling in cellular and subcellular levels, phosphopeptide enrichment and multiplex quantitation. Apply novel strategies to investigate the protein dynamic expression, location, modification and interaction in diverse model systems. 2. Application of quantitative proteomics in cell signaling: Monitor protein dynamic phosphorylation and find out new interactions and components in Wnt signaling pathways and adipocyte differentiation. 3. Application of quantitative proteomics in biomarker discovery of diabetes: Analyze the tissue and serum proteomes to track the progression of diabetes in human and animal models. 4. Investigation of regulation mechanism of protein dynamic behaviors: Combine Proteomic data with epigenetic, transcriptomic and MiRNA data etc., to reveal system-wide association of biological molecules.
Publications
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Deng WJ, Nie S, Dai J, Wu JR, Zeng R*. Proteome, phosphoproteome and hydroxyproteome of liver mitochondria in diabetic rats at early pathogenic stages. Mol Cell Proteomics. 2010, 9:100-16.
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Wu YB, Dai J, Yang XL, Li SJ, Zhao SL, Tang JS, Zheng GY, Li YX, Wu JR, Zeng R*. Concurrent quantification of proteome and phosphoproteome to reveal system-wide association of protein phosphorylation and gene expression. Mol Cell Proteomics. 2009, 8:2809-26.
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Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao Y, Ning ZB, Zeng R, Xiong Y, Guan KL, Zhao S, Zhao GP. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science. 2010, 327:1004-7.
