Zhou Jinqiu

Biography

ZHOU Jinqiu is a Professor Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Research Areas: histone modification; chromatin remodeling; telomere; cellular aging; cellular memory. Research Interests: The long-term goal of the lab is to understand the processes that eukaryotic cells faithfully maintain their chromosomes to avoid chromosomal instability. Currently, most of our work has been focused on the structure, function and replication of telomeres mainly using the baker’s yeast as a model. We use a combination of genetic, biochemical and cell biological approaches to address (1) how telomere length and structure are maintained, and the biological relevance of telomere regulation to genome stability and cellular ageing; (2) how a cell establishes the boundary between the telomere silent chromatin and adjacent active chromatin to prevent the telomeric hetrochromatin spreading; (3) what epigenetic codes and information are employed when telomere replication or DNA double-strand break occurs; (4) what is the molecular basis for telomere-length-dependent or -independent cellular aging.

Research Interest

The long-term goal of the lab is to understand the processes that eukaryotic cells faithfully maintain their chromosomes to avoid chromosomal instability. Currently, most of our work has been focused on the structure, function and replication of telomeres mainly using the baker’s yeast as a model. We use a combination of genetic, biochemical and cell biological approaches to address (1) how telomere length and structure are maintained, and the biological relevance of telomere regulation to genome stability and cellular ageing; (2) how a cell establishes the boundary between the telomere silent chromatin and adjacent active chromatin to prevent the telomeric hetrochromatin spreading; (3) what epigenetic codes and information are employed when telomere replication or DNA double-strand break occurs; (4) what is the molecular basis for telomere-length-dependent or -independent cellular aging.