Zou Weiguo
Professor
Biochemistry and Cell Biology
Shanghai Institutes for Biological Sciences
China
Biography
ZOU Weiguo is a Professor Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Research Interest
This laboratory focuses on systemically discovering the molecular and genetic mechanisms that govern bone development and bone remodeling, with the ultimate goal of the design of better therapeutics to treat bone diseases, such as osteoporosis, craniofacial anomalies and osteoarthritis, etc. The approaches employed in the laboratory include in vitro biochemistry, molecular and cellular biology and in vivo animal study, centering on skeleton biology of genetically manipulated mice. The topics we are interested in include: 1. Identifying novel regulators and pathways for osteoblast/osteoclast differentiation and function. 2. Studying the mechanisms of the coupling between bone formation and bone resorption. 3. Uncovering the pathological mechanisms of various skeletal disorders, such as osteoporosis, craniofacial anomalies and osteoarthritis, etc.
Publications
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Zou, W.*, Greenblatt, M.B.* (*co-first author), Shim, J.H., Kant, S., Zhai, B., Brady, B., Hu, D.Z., Gygi, S.P., Davis, R., Jones, D.C. and Glimcher, L.H. (2011) MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1. J Clin Invest . 121, 4383-92.
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Wan, L.*, Zou, W.* (*co-first author), Gao, D., Inuzuka, H., Drapp, R., Shaik, S., Eguren, M., Hu, D.Z., Malumbres, M., Glimcher L.H. and Wei W. (2011) Cdh1 Regulates Osteoblast functions through an APC/C-independent modulation of Smurf1. Molecular Cell. 44, 721-33.
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Zou, W., Chen, X., Shim, J.H., Huang, Z., Brady N., Hu, D.Z, Drapp, R., Sigrist, K., Glimcher, L.H. and Jones, D.C. (2011) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13, 59–65.
