Wei Guo

Biography

Oral mucosal melanoma (OMM) is a rare and aggressive form of melanoma accounting for 7.5% of all melanoma cases among Asians. We have been working to improve OMM's treatment effect and prognosis, by performing multidisciplinary therapy or targeted therapy. In our department, 5 years overall survival of OMM reached 30.3% and we have published 10+ related articles. We have performed exome sequencing on tumor tissues of ~40 OMMs (including matched tumor/normal tissue pairs and sole tumor), and we find several genes were recurrently mutated in OMM. Our interest is: based on our exome sequencing data, do data mining using bioinfomatic technique, to understand the potential pathogenesis mechanism of oral mucosal melanoma and to explore what clinical significance might OMM 's mutational profile have

Research Interest

interests (general) 1. Targeted therapy/chemotherapy of oral cancers 2. Exome sequencing analysis of Oral mucosal melanoma (OMM)