Wen Zhang
Professor
Department of physics
Shanghai Maritime University
China
Biography
Zhang Wen (1971-) associate professor. Master of Huazhong University of Science and Technology, research assistant in Institute of Biochemistry of CAS and UC Berkeley. Mr. Zhang focuses on structural and functional studies of ribosome including structural dynamics and mechanism for antibiotics resistance based on structural biology and bioinformatics. Representative achievements: solved the first structure of dynamic intermediate state at high-resolution during translation elongation; got two research grants from 973 Program and NSFC and the total amount is over RMB 1 million; applied for an international patent and got approved; publish papers in Science, Nature Struct Mol Biol, etc. as the first author which have been cited over 1200 times.
Research Interest
protein synthesis. Antimicrobial Agents hepatocellular carcinoma.
Publications
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erk V, Zhang W, Pai RD, Cate JH. Structural basis for mRNA and tRNA positioning on the ribosome. Proc Natl Acad Sci USA. 2006 Oct 24; 103(43): 15830-4
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Borovinskaya MA*, Pai RD*, Zhang W*, Schuwirth BS, Holton JM, Hirokawa G, Kaji H, Kaji A, Cate JH. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nature Struct Mol Biol. 2007 Aug; 14(8):727-32. (Important Progress cited by APS 2007 annual report ) *Equal contribution
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Pai RD*, Zhang W*, Schuwirth BS, Hirokawa G, Kaji H, Kaji A, Cate JHD. Structural Insights into Ribosome Recycling Factor Interactions with the 70S Ribosome. J Mol Biol. 2008 7; 376(5):1334-47. *Equal contribution
