Andrej Sali
Distinguished Professor-in-Residence
iHuman Institute
Shanghai Tech University
China
Biography
2016-present, Distinguished Adjunct Professor, ShanghaiTech University 2003-present, Professor, University of California,San Francisco 1995-2002, Assistant Professor and Associate Professor at the Rockfeller University. 1991-1995, Postdoc, Harvard University 1991, PhD, Birkbeck College, University of London, UK 1987, BSc in chemistry, University of Ljubljana, Slovenia.
Research Interest
We are using computation grounded in the laws of physics and evolution to study the structure and function of proteins. We aim to improve and apply methods for: 1.predicting the structures of proteins; 2.determining the structures of macromolecular assemblies; 3.annotating the functions of proteins using their structures. These research enhances the impact of genome sequencing, structural genomics, and functional genomics on biology and medicine.
Publications
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A. Ward, A. Sali, I. Wilson. Integrative structural biology. Science 339, 913-915, 2013.
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B. Pedersen, H. Kumar, A. Waight, A. Risenmay, Z. Roe-Zurz, B. Chau, A. Schlessinger, M. Bonomi, W. Harries, A. Sali, A. Johri,R. Stroud. Crystal structure of a eukaryotic phosphate transporter. Nature 496, 533-536, 2013.
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A. Waight, B. Pedersen, A. Schlessinger, M. Bonomi, B. Chau, Z. Roe-Zurz, A. Risenmay, A. Sali, R. Stroud. Structural basis for alternating access of a Eukaryotic Calcium/Proton exchanger. Nature 499, 107-110, 2013.
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J. Erzberger, F. Stengel, R. Pellarin, S. Zhang, T. Schaefer, C. Aylett, P. Cimermancic, D. Boehringer, A. Sali, R. Aebersold, N. Ban. Molecular architecture of the 40S•eIF1•eIF3 translation initiation complex. Cell 158, 1125-1135, 2014.
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P. Cimermancic, M.H. Medema, J. Claesen, K. Kurita, L. Wieland Brown, K. Mavrommatis, A. Pati, P.A. Godfrey, M. Koehrsen, J. Clardy, B.W. Birren, E. Takano, A. Sali, R.G. Linington, M. Fischbach. Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell 158, 412-421, 2014
