Chao-po Lin
Assistant Professor, PI
Life Science and Technology
Shanghai Tech University
China
Biography
1994.9-1998.6 B.S. in the Department of Zoology, National Taiwan University. 2000.9-2002.6 M.S. in the Institute of Genetics, National Yang-Ming University. 2002.9-2003.8 Research assistant, Institute of Microbiology, National Taiwan University College of Medicine. 2003.9-2010.1 Ph.D. in the Department of Pharmacology, Rutgers University, USA. 2010.4-2017.3 Postdoctoral fellow, University of California at Berkeley, USA. 2007.6-now Assistant Professor, PI, ShanghaiTech Uninversity, China
Research Interest
Our group is interested in the function(s) of microRNAs in pluripotent stem cells, as well as the function(s) of retrotransposons in mammalian development. First, we explore the importance of the p53-microRNA axis in somatic reprogramming, or the generation of induced pluripotent stem cells (iPSCs). Second, we study the roles of microRNAs in modulating the totipotent-like cell fate potential in pluripotent stem cells, a novel potency state of pluripotent stem cells we identified recently (Science, 2017). Finally, we investigate the functional roles of retrotransposons during mammalian pre-implantation and post-implantation development.
Publications
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Choi YJ*, Lin CP*, Ho J, Zhong Y, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks G, Hannon GJ and He L. (2010) miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 13:1353-60 (* equal contribution)
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Lin CP, Choi YJ, Hicks GG, and He L. (2011) The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle. 11:2063-72
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Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, and He L. (2013) A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 28(5): 438-50
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Choi YJ*, Lin CP*#, Risso D*, Chen S, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Kim SY, Speed TP, and He L#. (2017) Deficiency of miR-34a expands cell fate potential in pluripotent stem cells. Science. 10;355(6325) (* equal contribution; # corresponding author)
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1. Lin CP and He L. (2017) Noncoding RNAs in Cancer Development. Annual Reviews of Cancer Biology. 1:163-84.
