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Christopher L. Antos

Associate Professor, PI
Life Science and Technology
Shanghai Tech University
China

Biography

Dr. Antos obtained his B.S. Degrees from Indiana University in Bloomington in 1993. He then went to Freiburg, Germany on a Fulbright Scholarship and worked in the Laboratory of Dr. Rolf Kemler at the Max-Planck Institute for Immunology. In 1996, Dr. Antos started his Ph.D work in the laboratory of Dr. Eric Olson at UT Southwestern Medical Center at Dallas. After finishing his PhD, he then completed his post-doctoral training in the laboratory of Dr. Christiane Nüsslein-Volhard at the Max-Planck Institute for Developmental Biology in Tübingen, Germany from 2003-2007. In 2008, Dr. Antos established his own laboratory as faculty at the DFG-Center for Regenerative Therapies Dresden of the Technische Universität Dresden. Dr. Antos joined ShanghaiTech University as an Associate Professor, PI in Dec. 2016 and has adjunct afflication with Institut für Pharmakologie und Toxikologie at the Technische Universität Dresden (https://tu-dresden.de/med/mf/pt/forschung/ag-antos).

Research Interest

The Antos group researches tissue regeneration. To understand the biology of regeneration, Dr. Antos is interested in answering three fundamental questions: 1. How are cells at the site of injury induced to regenerate lost tissues? 2. How are cells involved in regeneration controlled to produce the correct pattern? 3. What stops regeneration once the appropriate size is reached? These questions are highly relevant to tissue bioengineering and to the stem cell biology of repair or reconstruction of human tissues. The Antos lab uses the zebrafish to answer these questions, because the zebrafish will regenerate many of its organs, including heart and appendages. Therefore, the lab can describe and dissect the cell and molecular mechanisms involved in the fish’s regeneration abilities and relate them to the limits on mammalian regeneration.

Publications

  • Kizil C, Küchler B, Yan J-J, Özhan G, Moro E, Argenton F, Brand M, Weidinger G & Antos CL (2014) Simplet/Fam53b (Smp) is required for Wnt signal transduction by regulating β-catenin nuclear localization. Development 141: 3529-3539.

  • Kujawski S, Lin W, Kitte F, Börmel M, Fuchs S, Arulmozhivarman G, Vogt S, Theil D, Zhang Y & Antos CL (2014) Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. Developmental Cell 28: 573-587

  • Antos CL, Knopf F & Brand M. (2015) Encyclopedia Article: “Regeneration of Organs and Appendages in Zebrafish: A Window into Underlying Cellular and Molecular Control Mechanisms”, Encyclopedia of Life Sciences, http://www.els.net/

  • Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS, El-Armouche A. (2017) Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity. Naunyn Schmiedebergs Arch Pharmacol. doi: 10.1007/s00210-017-1376-1. [Epub ahead of print]

  • Kolanowski TJ, Antos CL, Guan K. (2017) Making human cardiomyocytes up to date: Derivation, maturation state and perspectives. doi: 10.1007/s00210-017-1376-1. [Epub ahead of print]

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