Hui Zhang
Assistant Professor, PI
Life Science and Technology
Shanghai Tech University
China
Biography
2004.09-2008.06, B.A. in College of Animal Sciences and Technology, Huazhong Agriculture Universityï¼› 2008.09-2014.03, Ph.D. in Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciencesï¼› 2014.04-2016.03, Postdoc in Shanghai Institutes for Biological Sciences, Chinese Academy of Sciencesï¼› 2016.04-2016.10, Research fellow in Shanghai Institutes for Biological Sciences, Chinese Academy of Sciencesï¼› 2016.11 to Present, Assistant Professor, PI in School of Life Science and Technology, ShanghaiTech University. My previous work focused on cardiac development, especially endocardial development. Taking advantage of genetic lineage tracing, we identified the multipotency of embryonic endocardial endothelial cells, which could differentiate into cushion mesenchymal cells (Zhang et al, J Biol Chem, 2014), coronary endothelial cells (Tian et al, Cell Res, 2013; Tian et al, Science, 2014; Zhang et al, Circ Res, 2016), hepatic vascular endothelial cells (Zhang et al, Nat Genet, 2016), intramyocardial adipocytes (Zhang et al, Circ Res, 2016), and coronary mural cells (Chen et al, 2016, Nat Commun).
Research Interest
The cardiomyocytes of adult mammalian animals (such as human, mouse) have limited proliferation ability. Cardiomyocyte loss and fibrosis formation after cardiac injury (such as myocardial infarction) will result in heart failure and even death. However, the embryonic and neonatal cardiomyocytes have a strong ability to proliferate, which facilitates the regeneration of embryonic or neonatal hearts. Therefore, we are interested in the study of cardiovascular development and how to promote adult cardiac regeneration after injury. At present, we have generated a variety of mouse genetic tools and developed different disease models (such as myocardial infarction and apex resection). Utilizing lineage tracing and tissue-specific gene manipulation, we are to discover cell fate conversions of different cell types (such as cardiomyocyte progenitor cells, coronary endothelial cells, mesenchymal cells) and their molecular mechanisms during cardiovascular development, pathogenesis and regeneration. Our goals are to develop new potential treatment targets and improve repair and regeneration abilities of cardiovascular system.
Publications
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Zhang H, Pu W, Tian X, Huang X, He L, Liu Q, Li Y, Zhang L, He L, Liu K, Gillich A, Zhou B. Genetic lineage tracing identifies endocardial origin of liver vasculature. Nature genetics. 2016;48:537-543
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Zhang H, Pu W, Liu Q, He L, Huang X, Tian X, Zhang L, Nie Y, Hu S, Lui KO, Zhou B. Endocardium contributes to cardiac fat. Circulation research. 2016;118:254-265
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Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL, Camargo FD, Pu WT, Zhou B. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J Biol Chem. 2014;289:18681-18692
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Tian X#, Hu T#, Zhang H#, He L#, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, Zhou B. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014;345:90-94
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Tian X#, Hu T#, Zhang H#, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans SM, Gittenberger-de Groot AC, Red-Horse K, Zhou B. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell research. 2013;23:1075-1090
