Jianjun Cheng
Research Associate Professor
iHuman Institute
Shanghai Tech University
China
Biography
2001.09 – 2005.06 B.S. in Pharmaceutical Sciences College of Pharmacy, Shandong University (Jinan, Shandong) 2005.09 – 2010.07 Ph.D. in Medicinal Chemistry (Advisor: Yushe Yang) Shanghai Institute of Materia Medica, CAS (Shanghai, China) 2010.07 – 2013.10 Senior Scientist, Department Director Shanghai Huilun Life Science & Technology Co. Ltd (Shanghai, China) 2013.11 – 2016.03 Postdoctoral Research Associate (Advisor: Alan P. Kozikowski) College of Pharmacy, University of Illinois at Chicago (Chicago, USA) 2016.03 – present Research Associate Professor, Principle Investigator iHuman Institute, ShanghaiTech University (Shanghai, China)
Research Interest
GPCR targeted drug design, synthesis, and development.
Publications
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Cheng, J.*; Qin, J.; Guo, S.; Qiu, H.; Zhong, Y. Design, Synthesis and Evaluation of Novel HDAC Inhibitors as Potential Antitumor Agents. Bioorg Med Chem Lett ,2014, 24, 4768–4772.
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Cheng, J.; Giguere, P. M.; Lv, W.; Roth, B. L.; Kozikowski, A. P.* Design and Synthesis of (2-(5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)-methanamine as a Selective Serotonin 2C Agonist. Tetrahedron Lett, 2015, 56, 3420–3422.
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Cheng, J.; Giguere, P. M.; Onajole, O. K.; Lv, W.; Gaisin, A.; Gunosewoyo, H.; Schmerberg, C. M.; Pogorelov, V. M.; Rodriguiz, R. M.; Giulio Vistoli, G.; Wetsel, W. C.; Roth, B. L.; Kozikowski, A. P.* Optimization of 2-Phenylcyclopropylmethylamines as Selective Serotonin 2C Receptor Agonists and Their Evaluation as Potential Antipsychotic Agents. J Med Chem, 2015, 58, 1992–2002.
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Cheng, J.; Kozikowski, A. P.* We Need 2C but Not 2B: Developing Serotonin 2C (5-HT2C) Receptor Agonists for the Treatment of CNS Disorders. ChemMedChem ,2015, 10, 1963–1967.
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Cheng, J.; Giguere, P. M.; Schmerberg, C. M.; Pogorelov, V. M.; Rodriguiz, R. M.; Huang, X.-P.; Zhu, H.; McCorvy, J. D.; Wetsel, W. C.; Roth, B. L.; Kozikowski, A. P.* Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. J Med Chem, 2016, 59, 578–591.
