Margaret Su-chun
Lecturer
School of Life Science and Technology
Shanghai Tech University
China
Biography
B.A. Department of Molecular and Cellular Biology, Biochemistry 1995 - 1998 The University of California at Berkeley, CA Ph.D. Department of Molecular and Cellular Biology 1999 - 2003 Harvard University, Cambridge, MA Postdoctoral Fellow, Institute of Molecular Biology 2003 - 2010 Academia Sinica, Taiwan Professor, School of Medicine 2010 - 2017 Tongji University, Shanghai Associate Professor, PI, School of Life Science and Technology 2017.7-present ShanghaiTech University, Shanghai
Research Interest
Glia are the most abundant cell types in the nervous system and participate in virtually all aspects of brain function. Dysfunction in glial cells causes serious and significant pathology that leads to multiple brain diseases. In addition to our previous and current work on glia and neuronal development, my research interest focuses on the following aspects pertaining glial function, including 1) glial-mediated mechanism underlying neurodegeneration, 2) glial lipid droplets-based formation in pathological condition, and 3) optogenetic studies on the role of glia in neuronal circuits.
Publications
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Ho MS, Chen H, Chen M, Jacques C, Giangrande A, Chien CT Gcm protein degradation mediated by two F-box proteins suppresses proliferation of glial progenitors. Proc Natl Acad Sci U S A. 2009 106 (16):6778-83
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Xi X, Lu L, Zhuge CC, Chen X, Zhai Y, Cheng J, Mao H, Yang CC, Tan BC, Lee YN, Chien CT, Ho MS* The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation. Sci Rep. 2017 Jan 4;7:39856
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Song L, He Y, Ou J, Zhao Y, Li R, Cheng J, Lin CH, Ho MS* Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease. Cell Rep. 2017 Jan 31;18(5):1132-114
