Neurology
Global

Neurology Experts

Margaret Su-chun Ho

Associate Professor, PI
Life Science and Technology
Shanghai Tech University
China

Biography

B.A. Department of Molecular and Cellular Biology, Biochemistry. 1995 - 1998 The University of California at Berkeley, CA Ph.D. Department of Molecular and Cellular Biology. 1999 - 2003 Harvard University, Cambridge, MA Postdoctoral Fellow, Institute of Molecular Biology. 2003 - 2010 Academia Sinica, Taiwan Professor, School of Medicine. 2010 - 2017 Tongji University, Shanghai Associate Professor, PI, School of Life Science and Technology. 2017.7-present ShanghaiTech University, Shanghai

Research Interest

Glia are the most abundant cell types in the nervous system and participate in virtually all aspects of brain function. Dysfunction in glial cells causes serious and significant pathology that leads to multiple brain diseases. In addition to our previous and current work on glia and neuronal development, my research interest focuses on the following aspects pertaining glial function, including 1) glial-mediated mechanism underlying neurodegeneration, 2) glial lipid droplets-based formation in pathological condition, and 3) optogenetic studies on the role of glia in neuronal circuits.

Publications

  • Ho MS, Chen H, Chen M, Jacques C, Giangrande A, Chien CT Gcm protein degradation mediated by two F-box proteins suppresses proliferation of glial progenitors. Proc Natl Acad Sci U S A. 2009 106 (16):6778-83

  • Ho MS, Chen H, Chen M, Jacques C, Giangrande A, Chien CT Gcm protein degradation mediated by two F-box proteins suppresses proliferation of glial progenitors. Proc Natl Acad Sci U S A. 2009 106 (16):6778-83

  • Chen C, Yin S, Cao W, Ho MS* Drosophila ubiquitin E3 ligase dSmurf is required for synapse remodeling and axon pruning by glia. J Genet Genomics. 2017 Jan 20;44(1):67-70

  • Xi X, Lu L, Zhuge CC, Chen X, Zhai Y, Cheng J, Mao H, Yang CC, Tan BC, Lee YN, Chien CT, Ho MS* The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation. Sci Rep. 2017 Jan 4;7:39856

  • Xiao X, Chen C, Yu TM, Ou J, Rui M, Zhai Y, He Y, Xue L, Ho MS* Molecular Chaperone Calnexin Regulates the Function of Drosophila Sodium Channel Paralytic. Front Mol Neurosci. 2017 Mar 7;10:57

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