Min Zhuang
Assistant Professor, PI
Life Science and Technology
Shanghai Tech University
China
Biography
Dr. Min Zhuang graduated from the Department for Intensive Instruction (current name: Kuang Yaming Honors School), Nanjing University in 2003. She completed the graduate training at St Jude Children’s Research Hospital and obtained her Ph.D. degree from The University of Tennessee Health Science Center in 2009. She continued her postdoctoral training in the Department of Pharmaceutical Chemistry at University of California San Francisco. In 2014, she joined ShanghaiTech University as a tenure-track assistant professor, PI in the School of Life Sciences and Technology.
Research Interest
Protein posttranslational modifications play critical roles in regulating cellular events. Specific modulation of posttranslation enzymes, such as protein kinases, has been indicated to have therapeutic effect in many diseases. Recently, Ubiquitin-proteasome system (UPS) has emerged as the new target for drug discovery. My lab will focus on cancer related ubiquitin ligases. We will use a multidisciplinary approach involving protein engineering, mass spectrometry, structural biology and cellular biology to identify and validate novel ubiquitin ligase substrates, study ubiquitin ligase specificity, and discover potential drug targets.
Publications
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Zhuang M., Calabrese M.F., Liu J., Waddell M.B., Nourse A., Hammel M., Miller D.J., Walden H., Duda D.M., Seyedin S.N., Hoggard T., Harper J.W., White K.P., Schulman B.A.. Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell 36, 39-50, 2009. (Faculty of 1000: http://f1000.com/prime/1166991)
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Crawford E.D., Seaman J.E., Agard N., Hsu G.W., Julien O., Mahrus S., Nguyen H., Shimbo K., Yoshihara H.A., Zhuang M., Chalkley R.J., Wells J.A.. The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Mol Cell Proteomics 12, 813-824, 2013.
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Zhuang M., Guan S., Wang H., Burlingame A.L., and Wells J.A.. Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol Cell 49, 273-282, 2013. (Faculty of 1000: http://f1000.com/prime/717975954)
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Li G., Ci W., Karmakar S., Chen K., Dhar R., Fan Z., Guo Z., Zhang J., Ke Y., Wang L., Zhuang M., Hu S., Li X., Zhou L., Li X., Calabrese M.F., Watson E.R., Prasad S.M., Rinker-Schaeffer C., Eggener S.E., Stricker T., Tian Y., Schulman B.A., Liu J., White K.P.. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell 25, 1-14, 2014.
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Julien O.＊, Zhuang M.＊, Witta A.P., O’Donoghue A.J., Knudsen G.M., Craik C.S., Wells J.A.. Quantitative MS-based enzyme of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. PNAS 113(14) E2001-E2010, 2016. （＊equal contribution)
