Shuijin He
Assistant Professor, PI
Life Science and Technology
Shanghai Tech University
China
Biography
Dr. Shuijin received a B.A. degree in Biochemistry in 2000 from Lanzhou University and obtained a M.S. degree in Biophysics in 2003 from University of Science and Technology of China. He earned a Ph.D degree in Neuroscience in 2010 from Uniformed Services University of the Health Sciences in Maryland, US. He completed his postdoc training in 2015 at Memorial Sloan-Kettering Cancer Center in New York, US. He joined School of Life Sciences and Technology at ShanghaiTech University as an assistant professor, PI since 2015.
Research Interest
The mammalian neocortex progressively develops in a precise chronological order. Our main research interest is to understand the development of different neural activities in the embryonic neocortex and their roles in the formation of highly specific neuronal circuits of the adult mammalian neocortex. Currently, we particularly focus on the role of gap junction (electrical synapse) in the developing neocortex and the molecular mechanisms for gap junction formation. In addition, we are also interested in exploring the possibility of the utility of endogenous adult neural stem cells in the hippocampal dentate gyrus for a treatment of the temporal lobe epilepsy. We investigate these unanswered questions using a combination of experimental approaches including multiple-electrode whole-cell recordings, optogenetics, molecular cell biology, and imaging.
Publications
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Yu Y-C#*, He S #*, Chen S, Fu Y, Brown KN, Yao X-H, Ma J, Gao P, Sosinsky GE, Huang K and Shi S-H* (2012) Preferential electrical coupling regulates lineage-dependent microcircuit assembly in the neocortex. Nature 486(7401):113-7.
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He S, Shao L-R, Wang Y and Bausch SB (2013) Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition. J Neurophysiol.109(6): 1535-47.
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He S, Bausch SB (2014) Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis. Neuropharmacology 77: 379-86.
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Xu H-T, Han Z, Gao P, He S, Li Z, Shi W, Kodish O, Shao W, Brown KN, Huang K and Shi S-H. (2014) Distinct lineage-dependent structural and functional organization of the hippocampus. Cell 157(7): 1552-64.
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He S, Li Z, Ge S, Yu Y-C, Shi S-H (2015) Inside-out radial glial migration facilitates lineage-dependent microcircuit assembly in the neocortex. Neuron 86(5): 1159-66.
