Wenqing Shui
Professor
School of Life Science and Technology
Shanghai Tech University
China
Biography
Dr. Wenqing Shui graduated from Fudan University (Shanghai, China) with a master degree in 2004 and received Ph.D. at University of California (Berkeley, U.S.A.) with Dr. Carolyn Bertozzi and Dr. Jay Keasling in 2009. After her postdoctoral training at Thermo Fisher Scientific (San Jose, USA) as a bio-mass spectrometry application scientist, she joined School of Life Sciences in Nankai University (Tianjin, China) as Associate Professor from 2010 to 2015. During 2013-2015，she was Joint PI at Tianjin Institute of Industrial Biotechnology (TIB), Chinese Academy of Sciences. Then she joined TIB as PI from 2015 to 2016. Since April 2016, she joined ShanghaiTech university as an assistant professor at school of life science and technology and as a research associate professor(PI) at iHuman institute.
Research Interest
The main goal of Shui research group is to develop versatile mass spectrometry (MS)-based technologies for GPCR ligand discovery and cell signaling study. Over the years, our group has gained extensive experiences in developing high resolution mass spectrometry-centered analytical pipelines for comprehensive or targeted protein and metabolite analysis. Our expertise in proteomics and metabolomics research has been exploited to establish affinity mass spectrometry technology for ligand screening towards protein targets of therapeutic importance. These new approaches have unique advantages in building a high-throughput screening platform for early-phase drug discovery as well as probing receptor-drug interactions and signaling selectivity within the cell.
Publications
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Liu N, Xiong Y, Ren Y, Zhang L, He X, Wang X, Liu M, Li D, Shui W*, Zhou J*. Proteomic Profiling and Functional Characterization of Multiple Post-translational Modifications of Tubulin. Journal of Proteome Research 2015, 14, 3292-3304.
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Liu N, Xiong Y, Li S, Ren Y, He Q, Gao S, Zhou J*, Shui W*. New HDAC6-mediated deacetylation sites of tubulin in the mouse brain identified by quantitative mass spectrometry. Scientific Reports 2015, 5, 16869.
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Y, Guo Y, Xiao W, Cao Q, Li S, Qi X, Zhang Z, Wang Q*, Shui W*. An NGS-Independent Strategy for Proteome-Wide Identification of Single Amino Acid Polymorphisms by Mass Spectrometry. Analytical Chemistry 2016 Feb 8. [Epub ahead of print]
