Xuekai Zhu
Research Associate Professor
Entrepreneurship and Management
Shanghai Tech University
China
Biography
1998-2002 B.Sc. in microbiology, Anhui University, Hefei, China 2003-2005 M.Sc. in hydrobiology, Sun Yat-Sen University, Guangzhou, China 2005-2006 Research Assistant, Beijing Genomics Institute 2006-2010 Ph.D. in biochemistry and molecular biology, Institute of Microbiology,Chinese Academy of Sciences, Beijing, China 2010-2011 Postdoc, Institute of Microbiology, Chinese Academy of Sciences 2011-2015 Postdoc, University Hospital Freiburg, Germany 2015 (Jan.-June.) Postdoc, German Cancer Research Center (DKFZ) 2015.09-now Research Associate Professor, Principle Investigator，Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai,China
Research Interest
Developing engineered tumor-specific T cells for treating more cancer patients.
Publications
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Wang, L., Liu, X., Zhu, X., Wang, W., Liu, C., Cui, H., Sun, M., and Gao, B. (2013). Generation of single-domain antibody multimers with three different self-associating peptides. Protein Eng Des Sel 26, 417-423.
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Zhang, G., Liu, R., Zhu, X., Wang, L., Ma, J., Han, H., Wang, X., He, W., Wang, W., Liu, C., Li, S., Sun, M., and Gao, B. (2013). Retargeting NK-92 for anti-melanoma activity by a TCR-like single-domain antibody. Immunol Cell Biol 91, 615-624.
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Gaedicke, S., Braun, F., Prasad, S., Machein, M., Firat, E., Hettich, M., Gudihal, R., Zhu, X., Klingner, K., Schuler, J., Herold-Mende, C.C., Grosu, A.L., Behe, M., Weber, W., Macke, H., and Niedermann, G. (2014). Noninvasive positron emission tomography and fluorescence imaging of CD133+ tumor stem cells. Proc Natl Acad Sci U S A 111, E692- 701.
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Zhu, X., Prasad, S., Gaedicke, S., Hettich, M., Firat, E., and Niedermann, G. (2015). Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57. Oncotarget 6, 171-184.
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Zhu, X. and Niedermann, G. (2015). Rapid and efficient transfer of the T cell aging marker CD57 from glioblastoma stem cells to CAR T cells. Oncoscience 2,476-482.
