Xue-song Liu
Assistant Professor, PI
Life Science and Technology
Shanghai Tech University
China
Biography
Dr. Xue-Song Liu obtained his bachelor degree from School of Life Science, Wuhan University in 2002. He received his doctor degree from Institute of Health Sciences, Shanghai Institutes for Biological Sciences in 2007. He did his postdoc research in Medical School and School of Public Health of Harvard University from 2008 to 2015. Dr. Liu joined School of Life Science and Technology of ShanghaiTech University as an assistant professor, PI since June 2015.
Research Interest
Cancers are majorly caused by mutations or aberrant expression of cancer genes. We are interested in the molecular and genetic study of human cancer, and will use multiple approaches, including biochemistry, cell biology, bioinformatics and mouse model to study the genomics of human cancer. We will identify and study the function of novel cancer genes, particularly those genes that play roles in regulating chromatin structure and RNA biogenesis. We are also interested in therapeutically targeting cancer cells with defined common genetic alterations.
Publications
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Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes Dev. 2014, 28(17):1917-28. (Highlighted in Nature Reviews Cancer: Isabel Lokody, Nature Reviews Cancer, 14, 649 (2014))
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Liu XS, Little JB, Yuan ZM. Glycolytic metabolism influences global chromatin structure. Oncotarget. 2015, 6(6):4214-25.
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Liu XS, Genet MD, Haines JE, Mehanna EK, Wu S, Chen HI, Chen Y, Qureshi AA, Han J, Chen X, Fisher DE, Pandolfi PP, Yuan ZM. ZBTB7A suppresses melanoma metastasis by transcriptionally repressing MCAM. Mol Cancer Res. 2015, 13(8):1206-17.
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Liu XS*, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A*, Pandolfi PP. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nature Communications. 2015 Oct 8; 6:8325. doi: 10.1038/ncomms9325. (* co-first author)
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Liu XS, Liu Z, Gerarduzzi C, Choi DE, Ganapathy S, Pandolfi PP, Yuan ZM. Somatic human ZBTB7A zinc finger mutations promote cancer progression. Oncogene. 2015 Oct 12. doi: 10.1038/onc.2015.371.
