Zhijie Liu
Vice Director, Professor
iHuman Institute
Shanghai Tech University
China
Biography
1984 B.Sc. in Physics, Tianjin Normal University, China 1987 M.Sc. in Quantum Chemistry and Physical Chemistry, Tianjin University 1994 Ph.D. in Protein Crystallography, Institute of Biophysics, Chinese Academy of Sciences 1995-1995 Postdoctoral Fellow, Department of Crystallography, University of Pittsburgh 1995-1997 Postdoctoral Fellow, Department of Biochemistry & Molecular Biology, University of Georgia 1997-2002 Assistant Research Scientist, Department of Biochemistry & Molecular Biology, University of Georgia 2002-2005 Associate Research Scientist,Southeast Collaboratory for Structural Genomics (SECSG), Department of Biochemistry & Molecular Biology, University of Georgia 2005–2013 Professor, Institute of Biophysics, Chinese Academy of Sciences 2013–Present iHuman Institute, ShanghaiTech University
Research Interest
(1) Structural and functional analysis of proteins and multi-protein complexes in innate immune signaling pathway; (2) Structural proteomics of human liver disease related proteins and structure based drug design; (3) Development of new methods and new technologies in protein X-ray crystallography.
Publications
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Zhao, L., Hua, t., Crowley, C., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L., Huang, W., Liu, L., Ye, K., OuYang, S*, Cheng, G*, and Liu, ZJ*, (2014) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage, Cell Res, 24(3):344-58
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Liu B, Ouyang S, Makarova K, Xia Q, Zhu Y, Li Z, Guo L, Koonin E, Liu ZJ*, Huang L*. (2015) A primase subunit essential for efficient primer synthesis by an archaeal eukaryal-type primase. Nat Commun. 6: 7300.
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T. Hua, K. Vemuri, M. Pu, L. Qu, GW. Han, Y. Wu, S. Zhao, W. Shui, S. Li, A. Korde, R. Laprairie, E. Stahl, J. Ho, N. Zvonok, H. Zhou, I. Kurareva, B. Wu, Q. Zhao, M. Hanson, L. Bohn*, A. Makriyannis*, R Stevens*. Liu ZJ* (2016) Crystal Structure of the Human Cannabinoid Receptor CB1. Cell, 167(3):750-762.
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Song G, Yang D, Wang Y, Graaf C.D, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han G.W, Lau J, Wu B, Hanson M.A, Liu Z.J*, Wang M.W*, and Steven R.C* (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature, doi:10.1038/nature22378.
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(1) Structural and functional analysis of proteins and multi-protein complexes in innate immune signaling pathway; (2) Structural proteomics of human liver disease related proteins and structure based drug design; (3) Development of new methods and new technologies in protein X-ray crystallography.
