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Genetics Experts

Hou Chunhui

Associate Professor
Biology
South University of Science and Technology of China
China

Biography

Hou Chunhui has a multidisciplinary background, and in the gene sequencer research, gene editing, bioinformatics and other fields to achieve research breakthroughs.Presently, Hou Chunhui is assosiate professor of Department of Biology and Associate Professor, Southern University of Science and Technology. Hou Chunhui published many papers. He received the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences doctorate on 2014 and a bachelor's degree in microbiology and microbiology from Fudan University on 1997.

Research Interest

The three-dimensional tissue of chromatin has a direct effect on long-range transcriptional regulation, DNA recombination and chromosome translocation. We found that the eukaryotic genome is organized in a modular manner, but the reason for the formation of this tissue and the effects of various life activities on chromatin levels is unclear. We will improve and use experimental methods based on high-throughput sequencing techniques to study the changes and causes of chromatin spatial tissue at different stages of development and cell cycle, as well as the corresponding effects on life activities. At the same time, we will also use and invent new techniques to describe the spatial arrangement of regulatory elements and trans-factors associated with chromatin tissue and will use cell and model animal models to analyze the molecular mechanisms of regulation at all levels of the genome in genetic variation Related to the occurrence and development of the disease.

Publications

  • Hou CH, Zhao H, Tanimoto K, Dean A, (2008) CTCF-dependent enhancer blocking by alternative chromatin loop formation. PNAS 105: 20398-20403.

  • Hou CH, Dale R, Dean A, (2010) Cell type specificity of chromatin organization mediated by CTCF and cohesin. PNAS 107: 3651-3656.

  • Li Li, Xiaowen L, Hou C, Takenaka N, Huy Q, et al. (2015) Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-mediated Stress-induced Silencing. Mol Cell p: 58.

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