Huang Hongda

Biography

In 2004, he received a bachelor's degree from the College of Life Sciences, University of Science and Technology of China. He received his Ph.D. degree from the College of Life Sciences, University of Science and Technology of China in 2010. He is a member of the journalist and Professor Wu Jihui. 2011 - 2017 in the United States New York Sloan Kete Lin Cancer Research Center of Structural Biology in postdoctoral research, the tutor is the American Academy of Sciences Professor Dinshaw J. Patel. In early 2017 joined the Department of Biology, Southern University of Science and Technology.

Research Interest

is the epigenetics, focusing on the mechanism, three-dimensional structure and function of important protein complexes associated with DNA replication, repair and transcriptional regulation. Epigenetics studies a series of hereditary traits that do not depend on the DNA sequence and the mechanisms involved, including DNA methylation (with DNA methylation, demethylase and methylated DNA Identification proteins), histone modifications (such as methylation, acetylation, phosphorylation and ubiquitination, modification, production of various modifications and modifications of the enzyme, a variety of modified identification proteins, etc.), chromatin remodeling (such as Depending on the chromatin remodeling complex of ATP, etc.), histone variants (such as histone H3 and H2A variants), and histone chaperones. Epigenetic regulation can affect gene transcription, DNA replication, DNA repair, and cell development. Thus, the dysfunction of which important protein factors can lead to some human disease or even cancer. The structural studies of these important proteins or protein complexes help us to understand the pathogenesis of these proteins and provide the basis for the study of small molecule inhibitors and the treatment of diseases.