Zhang Xuomu
Professor
Chemistry
South University of Science and Technology of China
China
Biography
Zhang Xu Mu, born in 1961, is currently the professor of the Department of Chemistry, Southern University of Science and Technology, director of the Department, the executive director of the Shenzhen Grabus Research Institute. 1982 in Wuhan University received a bachelor's degree; 1985 in the Chinese Academy of Sciences, Fujian Institute of material structure obtained a master's degree, under the tutelage of Lu Jiaxi academician (Nobel laureate Linus Pauling postdoctoral, when he was president of the Chinese Academy of Sciences); 1987 in the University of California Prof. Gerhard N. Schauzer from the University of California, San Diego, received a Ph.D. from Stanford University in 1992. Professor James P. Collman, a member of the National Academy of Sciences, Bell Prize winner Sharpless and Grubbs); 1992-1994 postdoctoral research at Stanford University; 1994-1996 taught at Pennsylvania State University and was a lifelong professor; 1999 - 2000 received Guggenheim Fellowship, and in California Polytechnic Professor Grubbs (2005 Nobel Laureate) and Scripps Research Institute Professor Sharpless (2001 Nobel Laureate) do Sabbitical academic vacation for one year. In 2000, he was appointed professor of the Faculty of Chemistry of the New Jersey State University. In 2005, he was appointed professor of the Changjiang Scholar of the Ministry of Education and founded the Institute of Green Catalysis of Wuhan University. In 2008, he was appointed to Wuhan University In 2015, he served as professor of the Department of Chemistry, Southern University of Science and Technology, Department of the Department of the Department; in 2016 was elected national "thousands of people plan" friendship, the "thousands of people plan" Will be deputy director of the Chemical and Chemical Committee; 2017 was elected national "thousands of people plan" Association of chemical and chemical special committee director. Professor Zhang Xu Mu has long been engaged in highly efficient and highly selective catalytic research. Published more than 270 articles in academic journals such as Science; J. Am. Chem. Soc .; Angew. Chem. There are 50 papers, and he cited more than 15,000 times. > 75. Professor Zhang Xu Mu received the American Arthur C. Cope Scholar Award in 2002 and was the first Chinese scientist to win the award. Professor Zhang Xu Mu developed Zhang enyne cycloisomerization (Zhang enyne cycloisomerization) to become a Chinese name of the few (less than 5) one of the names of the reaction. Professor Zhang Xu Mu became one of the first six people in the year 2016 to be awarded the title of "Time of the Year", which led to the establishment of the first research institute in mainland China named after the Nobel Prize winner - Shenzhen Grabus Institute. Professor Zhang Xu Mu has long been in close contact with the domestic research institutes, served as the Chinese Academy of Sciences "homogeneous catalytic" international cooperation team overseas leaders, its concept of asymmetric synthesis was early adopted by the Natural Science Foundation Committee, and to promote the chiral Synthetic major project project, has a strong organizational leadership. Professor Zhang Xu Mu has many years of successful industrial application experience and background, such as asymmetric hydrogenation in the field of industrial applications in China and the world is absolutely leading position, the relevant major drugs such as ramipril, duloxetine and West The industrial application of green synthesis of Linchen intermediates is large in scale, small in pollution and extremely effective. In just a few years, the output value has reached several hundred million yuan and several years later, it will reach more than RMB100 million. Professor Zhang Xu Mu developed a number of major drug APIs have been successfully approved by the US FDA DMF (drug master file).
Research Interest
1, the development of efficient, highly selective asymmetric catalytic reaction chiral ligand kit; 2, the development of efficient, highly selective chemical catalytic reaction (asymmetric hydrogenation, asymmetric hydroformylation, linear hydroformylation, ester groups and amide compounds such as green reduction); 3, the catalytic reaction in the important drug intermediates and bioactive natural product synthesis in the application.
Publications
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Deng X, Ni S, Han Z, Dang L, Zhang X, et al. (2016) Enantioselective Rhodium-catalyzed Cycloisomerization of (E)-1,6-Enynes Angew Chem. Int Ed 55: p6295.
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You C, Wei B, Li X, Yang Y, Zhang X, et al. (2016) Rhodium-Catalyzed Desymmetrization by Hydroformylation of Cyclopentenes: Synthesis of Chiral Carbocyclic Nucleosides. Angew Chem Int Ed 55: p6511.
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Chen C, Jin S, Zhang Z, Wei B, Zhang Z, et al. (2016) Rhodium/Yanphos-Catalyzed Asymmetric Interrupted Intramolecular Hydroamino- Methylation of trans-1,2-Disubstituted Alkenes. J Am Chem Soc 138: p9017.