Dr. Zhixin Tian
Professor
School of Chemical Engineering and Technology
Tongji University
China
Biography
Dr. Zhixin Tian got his bachelor degree from Hunan Normal University in 1997; and PhD degree from Institute of Chemistry, Chinese Academy of Sciences in 2003. From 2004-2008, Dr. Tian did collaborative research with Prof. Steven R. Kass at University of Minnesota (Minneapolis, MN, USA); from 2008-2011, Dr. Tian did collaborative research with Dr. Richard D. Smith and Dr. Ljiljana Pasa-Tolic at Pacific Northwest National Laboratory (Richland, MN, USA). In 2011, Dr. Tian was awarded “Youth 1000-talents Program” of China and started independent research at Dalian Institute of Chemical Physics, Chinese Academy of Sciences; in 2013, Dr. Tian moved to Tongji University and began to lead the “Biological Analysis & Mass Spectrometry” group. Dr Tian’s current research interest is mainly mass spectrometry-based proteomics and glycomics. Quite a few novel methods and technologies, such as in situ interpretation algorithm of isotopic mass-to-charge ratio and envelope fingerprinting (iMEF), intact protein database search engine ProteinGoggle, protein universal pseudo-isobaric demethylation (PUPID), 2D orthogonal annotation of glycan topological structure, have been developed so far in the group.
Research Interest
1.New methods & technologies for proteomics 2.New methods & technologies for glycomics 3.Comparative proteomics 4.Comparative glycomics
Publications
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Fan Yu, Houqin Fang, Kaijie Xiao, Yan Liu, Bingbing Xue, Zhixin Tian*. Mass Measurement Accuracy of the Orbitrap in Intact Proteome Analysis. Rapid communications in Mass Spectrometry. 2016, 30, 1391-1397.
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Houqin Fang#, Kaijie Xiao#, Yunhui Li, Fan Yu, Yan Liu, Bingbing Xue, and Zhixin Tian*. Intact Protein Quantitation Using Pseudo-isobaric Dimethyl labeling. Analytical Chemistry, 2016, 88, 7198−7205
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Kaijie Xiao, Zhixin Tian*. Top-down characterization of histone H4 proteoforms with ProteinGoggle 2.0. Chinese Journal of Chromatography. Accepted.