Chen Mo

Biography

2001-2005 Bachelor of Science in Biology, Tsinghua University 2005-2011 PhD in Biology, Columbia University 2012-2017 Postdoctoral fellow at Rockefeller University

Research Interest

Tissue self-renewal and differentiation depend on the tissue-specific expression of transcription factors. When tissue cells become cancerous, the function of these transcription factors is altered by a variety of mutations that cause abnormalities in cell self-renewal and proliferation. These oncogenic genes are modified and regulate oncogenic transcriptional programs by a variety of proteins that bind directly to chromatin DNA; transcription factors that recruit epigenetic factors / Chromatin factors (chromatin factors), further modified chromatin to synergistically affect gene expression. These abnormal transcription programs can not only induce the occurrence of cancer, but also make cancer cells continue to grow. This phenomenon is known as the dependence of cancer cells on transcriptional program proteins, including transcription factors and epigenetic factors. These cancer-dependent transcription factors and epigenetic factors are likely to become the target proteins of clinical pharmaceuticals. It is of great practical value to study them. Our laboratory mainly studies how epigenetic factors work together with transcription factors to regulate the expression of specific genes in cancer cells, resulting in the dependence of cancer cells on these factors. 1. Acute myeloid leukemia depends on the molecular mechanism of JMJD1C protein Acute myeloid leukemia oncogene transcriptional regulation mechanism 3. To explore the digestive system of cancer for epigenetic dependence