Xun Lan

Biography

After graduating from Institute of Neuroscience, CAS, Dr. Guo       finished his postdoctoral training at Tsinghua University and then worked as a research scientist at GlaxoSmithKline, R&D, China. He had been the Co-PI of BaiLu’s lab at Tsinghua University since 2013, and accepted his current position as a research assistant professor of School of Pharmaceutical Sciences in 2015.

Research Interest

Constant immune surveillance prevents normal stem cells from uncontrolled proliferation; however, cancer cells evolve to evade the host immune system through various mechanisms. The immune genes related to “nonself” detection are extremely diverse in human population. Therefore, to better understand the mechanisms underlying immune escape and cancer development, it is important to use personalized approaches, which can integrate the genetic background of individual cancer patients. The Lan-Lab uses both experimental and computational approaches to study the interaction between cancer cells and the host immune system. We seek to gain insight into tumor immune escape, better understand the variability in patient response to cancer immunotherapies. We also use directed evolution to optimize the sensitivity and specificity of cancer cells recognition. Our ultimate goal is to improve the efficacy and prognosis of cancer immunotherapies by designing personalized treatment strategies.