Cai Gang
Professor
Life Sciences
University of Science and Technology of China
China
Biography
CAI Gang is presently working as a professor at school of life sciences, university of science and technology, China
Research Interest
Cryo electron microscopy (cryo-EM) is a powerful technique to study both the structure and dynamics of macromolecular complexes in their close to native state. I am interested in examining the structures and functional interactions of key macromolecular complexes responsible for regulation of eukaryotic transcription and chromatin structure, aiming at a structural understanding of the molecular mechanism.
Publications
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Cai, G., Imasaki, T., Yamada, K., Cardelli, F., Takagi, Y. & Asturias, F.J. Mediator head module structure and functional interactions. Nat Struct Mol Biol 17, 273-9 (2010).
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Imasaki, T., Calero, G., Cai, G., Tsai, K.L., Yamada, K., Cardelli, F., Erdjument-Bromage, H., Tempst, P., Berger, I., Kornberg, G.L., Asturias, F.J., Kornberg, R.D., Takagi, Y. Architecture of the Mediator head module. Nature 475, 240-3 (2011).
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.Cai, G., Chaban, Y., Imasaki, T., Kovacs, J.A., Calero, G., Penczek, P.A., Takagi, Y., Asturias, F.J. Interaction of the Mediator Head Module with RNA Polymerase II, Structure (2012), doi:10.1016/j.str.2012.02.023
