Gao Ping
Professor
Life Sciences
University of Science and Technology of China
China
Biography
Ping is presently working as a professor at school of life sciences, university of science and technology, China
Research Interest
Gao Lab is focused on studying the cellular metabolism, cancer metabolism in particular, to explore the new strategy for cancer therapy. It is known that cancer cells generally adapt a specific metabolic phenotype that is characterized by the switch to aerobic glycolysis, or Warburg Effect. While this metabolic phenotype is largely believed to be responsible for the growth advantage of cancer cells in general, the underlying mechanisms are still elusive. Dr. Gao and others recently discovered that oncogene cMyc-regulated glutamine metabolism is also important for cancer growth (Gao et al, Nature 2009), hence, his group is currently exploring oncogenic regulation of glucose and amino acids metabolism in cancer cells and its significance in cancer development. Moreover, because of the overlapping molecular features of stem cells with cancer cells, Dr. Gao’s group is also studying the potential critical role and the underlying mechanisms for metabolic switch in pluripotent stem cells. Dr. Gao is currently supported by National Key Basic Research Program of China (973 Program), the Natural Science Foundation of China, and the Chinese Academy of Sciences.
Publications
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Ma X＃, Li C＃, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P* and Zhang H*. Lin28/let-7 Axis Regulates Aerobic Glycolysis and Cancer Progression via PDK1. Nature Communications 2014 ;5:5212. doi: 10.1038/ncomms6212.
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Sun, L. , Song, L. , Wan, Q., Wu, G., Li, X., Wang, Y., Wang, J., Liu, Z., Zhong, X., He, X., Shen, S., Pan, X., Li, A., Wang, Y., Gao, P.*, Tang, H.*, and Zhang, H*. cMyc-Mediated Activation of Serine Biosynthesis Pathway is Critical for Cancer Progression under Nutrient Deprivation Conditions. Cell Research. 2015 Apr. (In Press)
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Cao, Y., Guo, W. T., Tian, S., He, X., Wang, X. W., Liu, X., Gu, K. L., Ma, X., Huang, Hu, L., Cai, Y., Zhang, H., Wang, Y.*, and Gao, P*.　 miR-290/371-Mbd2-Myc Circuit Regulates Glycolytic Metabolism to Promote　 Pluripotency. EMBO J. 2015 Jan 20. pii: e201490441.
