Jiang-ning Zhou
Professor
School of Life Sciences
University of Science and Technology of China
China
Biography
Jiang-Ning Zhou is the Professor in the School of Life Science of University of Science and Technology of China.
Research Interest
My laboratory pursues two lines of research which are funded by the Ministry of Science and Technology of China and Nature Science Foundation of China. In the first project, we are interested in how the interaction between ApoE gene and environment factors be involved in the pathogenesis of Alzheimer’s disease. In the second project, we are studying the mechanism of multiple receptors regulate the activity of corticotrophin releasing hormone neurons in hypothalamus in stress response and depression. The aim of both research lines is to find putative factors and targets for therapeutic strategies. Several experimental approaches are used in these research, including behavioral, microdialysis in free running animal, cell culture, patch clamp electrophysiology, and a variety of molecular and biochemical techniques. Our work on the human hypothalamus is carried out in collaboration with Prof. Swaab in the Netherlands Institute for Neuroscience.
Publications
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Wu L, Sluiter AA, Guo HF, Balesar RA, Swaab DF, Zhou JN, Verwer RW. 2007. Neural stem cells improve neuronal survival in cultured postmortem brain tissue from aged and Alzheimer patients. J Cell Mol Med. 12:1611-21.
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Wang SS, Willem Kamphuis, Inge Huitinga, Zhou JN, D.F. Swaab. 2008. Gene Expression Analysis in the Human Hypothalamus in Depression by Laser Micro-Dissection and Real Time PCR: the presence of multiple receptor imbalances. Molecular Psychiatry. 13:786-99.
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Chen XN, Meng QY, Bao AM, Swaab DF, Wang GH, Zhou JN.2009. The involvement of retinoic acid receptor-α in corticotropin-releasing hormone gene expression and affective disorders. Biological Psychiatry published online doi:10.1016/j.biopsych.
