Sun Rui

Biography

Prof. Sun Rui is a professor and Ph.D. supervisor at School of Life Sciences, USTC. She used to serve as deputy director of Shandong Key Laboratory for Tumor Immunity and Genetic Engineering, Institute of Basic Medical Sciences, Shandong Academy of Medical Sciences. She was appointed as master’s supervisor in 1996 and researcher in 1998. From August 1995 to August 1996 and from March 2001 to March 2003 she made cooperative studies on tumor immunology and liver immunology at Institute of Cancer Research (ICR) and National Institute of Alcohol Abuse and Alcoholism (NIAAA), U.S. National Institutes of Health (NIH). In 1994 she won the fourth “China Youth Science and Technology Award”, enjoyed the special governmental allowance financed by State Council in 1998, and the “Distinguished Researcher Award” of U.S. National Institutes of Health in 2005. Currently she reserves as standing member of Infection Immunity Branch Society, Chinese Society for Immunology, and member of editorial board of Chinese Journal of Immunology. She has specialized in tolerance mechanism of innate immunity of liver and liver immunopathology, systematically studied that IL-6 protects liver from autoimmune liver injury through inhibiting STAT3 signaling pathway (J Immnol 2004), found NK cells of liver and its generated IFN-gamma have a negative regulation of liver generation (Gastroenterology 2004), discovered innate immune recognition receptors NKG2D are able to inhibit liver fibrosis through control of hepatic stellate cells (Ganstroenterology 2006ï¼›Hepatology 2006), etc. In the meantime she has carried on molecular immunology and structural immunology research and centered on Several innate immune recognition receptor families and signaling molecules to study the relationship between innate immunological function and molecular structures. Her research results once won three second prizes of Provincial/Ministerial Level Scientific and Technological Progress Award”. As a principal investigator, her study “Mediated Liver Injury, Regenerated Innate Immune Recognition and Its Regulatory Mechanism” won the prize of Chinese Medical Sciences & Technology Award 2007, the first prize of Anhui Province Natural Science Award in 2007, and the second prize of State Natural Science Award in 2008.

Research Interest

1. Innate immune receptors of NK or NKT cells in liver diseases.  2. Innate immune receptors in tumor immunotherapy 3. Recognition mechanisms of innate immune receptors.