Tian Changlin
Professor
School of Life Sciences
University of Science and Technology of China
China
Biography
Tian Changlin 1991-July 1995, Undergraduate (Two Bachelor’s Degrees in Engineering) Majoring in Biochemical Engineering at Department of Biological Science and Technology, and Applied Electronic Technology at Department of Information and Control Engineering of Shanghai Jiaotong University; September 1995-July 1997, Master’s Degree, Majoring in Molecular Biology at Department of Biological Science and Technology of Shanghai Jiaotong University; August 1997-May 2003, Ph.D., Majoring in Biophysics at Institute of Molecular Biophysics of Florida State University) May 2003-November 2006, Postdoctoral Fellow at the Center of Structural Biology of Department of Biochemistry of Vanderbilt University
Research Interest
Developing biophysical methods to analyze protein-protein interactions and protein dynamic properties in-situ or in native cellular (both prokaryotic and eukaryotic) environments. The methods include nuclear magnetic resonance (NMR), electron spin resonance (ESR), fluorescence and other related spectroscopic methods. Structure and function studies of ion channels. Using the combinational structural biology methods to illustrate three dimensional structures of ion channels, modulatory subunits and/or native toxins. Using the patch-clamp methods to illustrate physiological behavior of ion channels and their functional variations under different modulatory molecules.
Publications
-
Li J, Shi C, Sun D, He Y, Lai C, Lv P, Xiong Y, Zhang L, Wu F, Tian C. The HAB1 PP2C is inhibited by ABA-dependent PYL10 interaction.Sci Rep. 2015Jun5;5:10890.doi: 10.1038/srep10890.
-
Sun P, Wu F, Wen M, Yang X, Wang C, Li Y, He S, Zhang L, Zhang Y, Tian C. A distinct three-helix centipede toxin SSD609 inhibits I(ks) channels by interacting with the KCNE1 auxiliary subunit.Sci Rep. 2015 Aug 26;5:13399. doi: 10.1038/srep13399. PMID：26307551.
-
Liu S, Lv P, Li D, Guo X, Zhang B, Yu M, Li D, Xiong Y, Zhang L, Tian C. K(+) preference at the NaK channel entrance revealed by fluorescence lifetime and anisotropy analysis of site-specifically incorporated (7-hydroxycoumarin-4-yl)ethylglycine.Chem Commun (Camb). 2015 Nov 14;51(88):15971-4. doi: 10.1039/c5cc06124e. Epub 2015 Sep.
