Zang Jianye
Professor
School of Life Sciences
University of Science and Technology of China
China
Biography
Jianye Zang is the Professor in the department of School of life science of University of Science and Technology of China.
Research Interest
Covalent modifications of histone, including methylation, acetylation, phosphorylation, ubiquitination, and so on, are crucial for various biological processes. The same modification read by different “readers” will produce different biological outcomes. Each modification is dynamically controlled by the interplay of "writers" with "erasers", which may be established when special signal presents. After establishment, some of these modifications are able to be maintained at specific site and are inheritable, even if the triggering signals disappeared. In addition, enzymatic activities of the enzymes participating in modification of histones are tightly regulated. We are interested in the mechanisms of recruitment of these enzymes to target genes. The mechanisms of enzymatic activity regulation are also interesting question to us. We will use X-ray crystallographic, biochemical,molecular biology and other biophysical techniques to explore these fascinating questions.
Publications
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Interaction of JMJD6 with single-stranded RNA , Proc. Natl. Acad. Sci. USA , 2010 , 107, 14568-72.
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Crystal structure of Sa240: A ribose pyranase homolog with partial active site from Staphylococcus aureus , J Struct Biol. , 2011 , 174(2): 413-9.
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Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. , EMBO J. , 2011 , 30, 2829-42.
