Zhang Huafeng
Professor
School of Life Sciences
University of Science and Technology of China
China
Biography
ZHANG Huafeng, selected into Hundred Talents Program of CAS, is a doctoral supervisor. In 1997, she graduated from the Department of Pharmacy (instruction in Japanese), Shenyang Pharmaceutical University and earned her master’s degree in pharmacology. She earned her PhD. From University of Tokyo in Japan in 2004. She did her postdoctoral research at National Cancer Institute of NIH from 2004 to 2005 and in Medical School of Johns Hopkins University from 2005 to 2008. She worked at Johns Hopkins as a research scientist from 2008 to 2010, studying mainly the role of hypoxia or anoxia in cancer development. Her achievements were published in famous journals such as Cancer Cell, Cell, PNAS, and Cancer Research and were also reported by the Washington Post.
Research Interest
The major research interest of Dr. Huafeng Zhang is to decipher molecular basis underlying hypoxia and HIF (Hypoxic-inducible-factor) -mediated tumorigenesis and tumor development. Apart from mechanistic studies, screening for HIF1-specific inhibitors for cancer therapy is also under way in her lab.
Publications
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Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Wang Y, Gao P*, Tang H*, Zhang H* cMyc-Mediated Activation of Serine Biosynthesis Pathway is Critical for Cancer Progression under Nutrient Deprivation Conditions. Cell Research 2015 Apr;25(4):429-44.
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Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P and Zhang H* HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation is Critical for Cancer Progression. Cell Reports 2014 Sep 25;8(6):1930-42.
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Huang D, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin S, Dang CV, Song L*, Gao P*, Zhang H*. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition stress. Cell Research. 2016; 26(10): 1112-1130.
