Marx Steven O
Department of Pharmacology
Columbia University Medical Center
He is professsor at Columbia University.
The Marx laboratory studies the regulation of ion channels by macromolecular complexes. We have demonstrated that specific sequences within the ion channel (leucine zippers) recruit regulatory proteins, which modulate the ion channel function in normal and pathologic conditions. The laboratory is now focused on understanding the molecular components and functional implications of macromolecular complex formation of the large conductance calcium-activated potassium channel (BKCa, maxi-K) and the L-type voltage gated calcium channel. The laboratory utilizes both molecular biologic and electrophysiologic (planar lipid bilayer, patch clamp) techniques to elucidate these fundamental processes and emphasizes the links between these fundamental molecular processes and systems function. To date our work has had significant impact in understanding the triggers of fatal cardiac arrhythmias and mechanical dysfunction in heart failure. Present experiments are very likely to impact our understanding of control of peripheral blood pressure by the sympathetic nervous system.