Global

Pathology Experts

Richard N. Mitchell

Associate Director
Department of Pathology
Harvard Medical School
Colombia

Biography

The Mitchell laboratory conducts research at the interface of immunology and vascular cell biology. Focusing on the mechanisms underlying acute and chronic rejection in solid organ allografts, the work involves mouse transplant models, as well as human clinical transplantation, focusing on understanding specific immunologic pathways that drive rejection and ultimately graft failure. The laboratory is particularly interested in the mechanisms that induce the process of allograft arteriopathy whereby allograft vessels become progressively more occluded until the grafts suffer irreversible ischemic injury. The research may have much broader applicability, since the inflammatory mediators that drive the occlusive process in transplants may also be involved in mediating the vascular wall thickening that characterizes more “typical” atherosclerosis. The laboratory uses several different strains of genetically engineered mice, deficient either in cell surface molecules that promote the cellular cross-talk necessary to promote rejection, or lacking particular cytokine or chemokine mediators or their receptors. In collaboration with other members of the Harvard and MIT communities, as well as industry (Schering-Plough, Bristol Myers-Squibb, and Novartis) the group has also evaluated promising interventions to prevent allograft arteriop.

Research Interest

Pathology and Health Sciences and Technology immunology and vascular cell biology grafts suffer irreversible ischemic injury.

Global Experts from Colombia

Global Experts in Subject

Share This Profile
Recent Expert Updates
  • Matthew L Stone
    Matthew L Stone
    pediatrics
    University of Virginia Health System; Charlottesville, VA
    United States of America
  • Dr.   Matthew
    Dr. Matthew
    pediatrics
    University of Virginia Health System; Charlottesville, VA
    United States of America
  • Dr.  L Stone Matthew
    Dr. L Stone Matthew
    pediatrics
    University of Virginia Health System; Charlottesville, VA
    United States of America
  • Dr.  L Stone
    Dr. L Stone
    pediatrics
    University of Virginia Health System; Charlottesville, VA
    United States of America
  • Dr. Matthew L Stone
    Dr. Matthew L Stone
    pediatrics
    University of Virginia Health System; Charlottesville, VA
    United States of America
  • Dr.  R Sameh
    Dr. R Sameh
    pediatrics
    King Abdul Aziz University
    United Arab Emirates
  • Dr.   R Ismail,
    Dr. R Ismail,
    pediatrics
    King Abdul Aziz University
    United Arab Emirates
  • Sameh R Ismail,
    Sameh R Ismail,
    pediatrics
    King Abdul Aziz University
    United Arab Emirates
  • Dr.   Sameh R Ismail,
    Dr. Sameh R Ismail,
    pediatrics
    King Abdul Aziz University
    United Arab Emirates
  • Dr.   William
    Dr. William
    pediatrics
    Maimonides Medical Center
    United States of America