Biomedical Sciences

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Leondios G. Kostrikis

Department of Biological Sciences
Cyprus University of Technology


Dr. Leondios Kostrikis is a tenured Professor of Biotechnology and Virology at University of Cyprus, Head of Laboratory of Biotechnology and Molecular Virology and Vice-Chairperson of the Department of Biological Sciences. He received his B.Sc. (1987), M.Sc. (1989), M.Ph. (1990) and Ph.D. (1993) degrees from New York University (NYU), United States. This was followed by post-doctoral research at the Aaron Diamond AIDS Research Center of Rockefeller University (New York) on the molecular virology of human immunodeficiency virus. He joined the faculty of the Aaron Diamond AIDS Research Center as a staff investigator in 1998 and the Rockefeller University as an Assistant Professor in 1999. He moved to Cyprus in 2003, joining the University of Cyprus He was a Fulbright Scholar for his undergraduate studies at NYU (1983-1987) and has held fellowship awards from the Elizabeth Glazer Pediatric AIDS Foundation, the Aaron Diamond Foundation and the Patti Birch 1991 Trust, United States. He has directed over twenty competitive research grants from the US National Institutes of Health (NIH), the European Commission, international charitable foundations and the Cyprus Research Promotion Foundation (CRPF). He is an Editorial Board member for seven international journals, and has served on study sections and committees for European and international grant agencies, charities, and scientific conferences in HIV/AIDS. He is a co-founder and Executive Board member of the European Society for T

Research Interest

Dr. Kostrikis is an internationally recognized scientist in the field of HIV/AIDS, who has made important indepentent contributions to the study of human genetics in the transmission of HIV-1 and disease progression, global molecular epidemiology of HIV-1 infection, and HIV-1 drug resistance. His laboratory continues to work on HIV-1 transmission and pathogenesis and how host and viral factors may influence the progression of the disease; studying the mechanisms of drug resistance development during HIV antiretroviral therapy; understanding the implications of natural genetic diversity in efficacy of antiretroviral drugs; studying the molecular phylogeography of HIV-1 and HCV infection in Europe; and developing novel HIV-1 immonogens and vaccination strategies for mucosal and systemic immunity. Dr. Kostrikis has now turned his attention to novel concepts in HIV vaccine development and prevention of HIV-1 transmission.


  • Karanicolas R., Allers K., Joos B., Weber Kostrikis L. G. Gunthard H et al.2003 Emergence of Minor Populations of Human Immunodefieciency Virus Type 1 Carrying the M184V and L90M Mutations in Subjects Undergoing Structured Treatment Interruptions. J. Infect. Diseases 188(10): 1433-1443.

  • Loizidou E., Kousiappa I., Themistocleous G., Zeinalipour-Yazdi C. D.,Kostrikis L. G, et al.2009 Implications of HIV-1 M-Group Polymorphisms on Integrase Inhibitor Efficacy and Resistance: Genetic and Structural in-silico Analysis. Biochemistry 48(1): 4-6.

  • Demetriou V. L, van de Vijver D. A. M. C., Kousiappa I., Balotta C., Vercauteren J. Kostrikis al. 2010 Cellular HIV-1 DNA Levels in Drug Sensitive Strains are Equivalent to Those in Drug Resistant Rtrains in Newly-Diagnosed Patients in Europe. PLoS One 5(6) e10976.

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