Paris A. Skourides
Department of Biological Sciences
Cyprus University of Technology
1998-2004 PhD, The Rockefeller University. Morphogenetic Movements during the Xenopus Gastrulation and Development of Biocompatible Quantum Dots. 1994-1997 B.A. Biochemistry, Brandeis University. Summa Cum Laude and Highest Honors in Biochemistry
he goal of our research group is to understand the cellular and molecular mechanisms involved in generating the three dimensional organization of tissues and the overall process by which the basic body plan of vertebrate embryos is established. During gastrulation cell and tissue movements on a massive scale create great complexity from a very simple starting form, resulting in highly diversified organisms with a precise three dimensional architecture.Elucidating the mechanisms underlying these movements is important, because genetic mutations and environmental insults during gastrulation can lead to significant developmental deformities. A comprehensive understanding of this process and how it is affected by genetic mutations will help develop diagnostic and therapeutic tools for dealing with human developmental disorders. The study of gastrulation and morphogenetic movements has always demanded cutting edge imaging and the pace of discovery in the field has been set by advances in imaging technologies. The complexity of morphogenetic movements together with our inability to image them in vivo has forced researchers to study each movement isolated from the others. Yet if we are to truly comprehend the way morphogenetic movements give rise to form we need to begin the process of integrating what we know back to the embryo and view gastrulation as a unified process rather than individual components. Our laboratory with the use of nanotechnology and specifically the application of Quantum Dot nanocrystals is developing new imaging methods and technologies which enable the study of morphogenesis at the organismal, cellular and molecular level in vivo. In addition we are exploring the development of new types of nanocrystals and a number of wide ranging applications for Quantum Dots in Biology.
Petridou NI, Stylianou P, Skourides PA. A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis. Development. 2013 Sep 18
Zanardelli S, Christodoulou N, Skourides PA.Calpain2 protease: A new member of the Wnt/Ca2+ pathway modulating convergent extension movements in Xenopus. Dev Biol. 2013 Sep 26.
Antoniades I, Stylianou P, Skourides PA, Making the connection: ciliary adhesion complexes anchor Basal bodies to the actin cytoskeleton. Dev Cell. 2014 Jan 13;28(1):70-80. doi: 10.1016/j.devcel.2013.12.003.