Biomedical Sciences
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Biomedical Sciences Experts

Vasilis J. Promponas

ASSISTANT PROFESSOR
Department of Biological Sciences
Cyprus University of Technology
Cyprus

Biography

2012-: Assistant Professor in Bioinformatics, Department of Biological Sciences, University of Cyprus 2005-2012: Lecturer in Bioinformatics, Department of Biological Sciences, University of Cyprus 2005-: Head, Bioinformatics Research Laboratory, Department of Biological Sciences, University of Cyprus 2004-2005: Post Doctorate Research Assistant, Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Greece 1997-2004 PhD in Biological Sciences: Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Greece. Thesis title: “Prediction of protein function from aminoacid sequence”. 1991-1996 BSc in Physics: University of Athens, Greece. Diploma thesis title: “Structural and Modeling studies of possible inhibitors of the enzyme Dihydrofolate Reductase (DHFR)”.

Research Interest

Understanding the principles of microbial genome structure, function and evolution through comparative genomics approaches. Large Scale Comparative Genomics and Computer Assisted Genome Annotation. Genomic data analysis and visualization.Sequence repeats, low complexity/compositionally biased regions: Investigation of their relation to protein structure and association to protein (mis)function. Study of the evolution of protein repeats. Development of new methods and algorithms.Evolution of transmembrane and membrane-associated proteins. Applications on classification, function, topology and structure preciction based on complete genomic data statistical and machine learning approaches. Simulation of native or ‘in silico engineered’ membrane proteins.Application of Statistical, Machine Learning and Data Mining techniques in Biological Sequence Analysis.Computational Approaches towards Systems and Synthetic Biology.

Publications

  • Papanikolaou N, Trachana K, Theodosiou T, Promponas VJ *, and Iliopoulos I *.Gene socialization: gene order, GC content and gene silencing in Salmonella (2008, submitted)Published

  • Kirmitzoglou I, and Promponas VJ *.A novel, efficient and sensitive approach for searching large protein sequence databases(2008, in preparation)

  • Mitilinaiou E, Kirmitzoglou I, and Promponas VJ *.Comparative analysis of low complexity regions in proteins encoded in the complete genomes of Arabidopsis thaliana and Oryza sativa indica(2008, in preparation)

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