Dr.luc Teyton

Biography

 Dr.Luc's laboratory is trying to elucidate the molecular mechanisms by which the ligation of the T cell receptor to its ligand, an MHC-peptide complex, activates T cells.And aim to have crystallized and solved the structure of two TCR/pMHC complexes. No conformational changes were evidenced in these complexes. so they are trying now to reconstruct a larger TCR complex including CD3 dimers and CD4/CD8 molecules. Similar studies are carried out on TCR/pMHC pairs involved in autoimmune diseases with two additional goals. First, identify self-peptides involved in autoimmunity. Secondly, measure the affinity of self MHC-self pMHC complexes and determine if pathogenic T cells arise from escaping negative selection or breakage of peripheral tolerance. The corollary question is to determine if autoimmunity is a deviance of a normal immune response or the innate property of a T cell response against a self antigen. The answers to these questions will be determinant in choosing new therapeutic strategies. Dr.Luc was faculty and professor in Immunology department in Scrippa university and he obtained his Ph.d in immunology from University of paris Diderot. And has more than 10 publications based on therapeutics and immunology.

Research Interest

 Dr.Luc's work interest is basically based on T-cell and MHC-peptides.apart from that he is focused to have a drug design in immunological way which act as a defence master for diseases like cancer and other immunological disorder.