Gambino Frédéric

Biography

Frédéric Gambino’s research goal is to understand how neuronal networks of behaving animals modulate the structure of their synaptic connections in response to learning, and how this process regulates the dynamics of representations that drive complex behaviors such as associative fear learning, decision-making, and action selection. Frédéric Gambino first joined the lab of Pr B. Poulain and Y. Humeau (Strasbourg, France) as a PhD student (2006-2009). He developed patch-clamp and two-photon imaging in vitro strategies to study the properties of long-term synaptic potentiation (LTP), the main synaptic proxy of memories, in several animal models for cognitive disorder (CD). He showed that mice deficient for CD genes Ophn1, Rsk2 and Il1rapl1 exhibit a specific deficit in the non-canonical expression of presynaptic LTP caused by the selective uncoupling of evoked glutamate release from cAMP presynaptic. His PhD work led to 8 publications in high-standard journals.   

Research Interest

Neurology